A.G.E. Interrupter Advanced is a potent wrinkle cream that helps reverse visible signs of aging, including fine lines and deep wrinkles, caused by collagen decline and glycation.

Backed by more than 15 years of glycation research and expertise, A.G.E. Interrupter Advanced is a potent anti-wrinkle cream that helps correct and defend against visible signs of aging. Formulated with 18% concentrated ProxylaneTM, 4.25% wild fruit flavonoids and 0.1% glycyrrhetinic acid, this breakthrough anti-aging moisturizer is clinically proven to help reverse skin-aging glycation by up to 33%. A.G.E Interrupter Advanced contains a high performance formula that is clinically shown to smooth visible lines and deep wrinkles in five facial zones, reduce visible discoloration, and restore skin density. Physician tested to complement RF microneedling treatments for 3x better lifting results in 12 weeks. Physician-tested with GLP-1 patients, A.G.E. Interrupter Advanced, paired with A.G.E. Interrupter Ultra Serum and lifting ultrasound treaments reduce skin laxity -20% vs control in 12 weeks.

What is Skin Glycation?
Glycation is natural process that accelerates visible signs of aging. During the glycation process, excess sugars bind to skin-supporting proteins (like collagen and elastin) and form advanced glycation end-products (A.G.E.s). A.G.E.s weaken collagen, leading to wrinkles and laxity.

Signs of Glycation
Wrinkling and crepiness
Loss of firmness
Dull, sallow complexion

Glycation Dos and Don’ts
DO: Wear Sunscreen
Protect skin from UV damage and oxidative stress by applying broad-spectrum sunscreen daily.

DO: Reduce Sugar
Alcohol consumption and high-sugar diets can promote the glycation process.

DON’T: Expose Skin to Smoke
Cigarette smoke deposits a myriad of chemicals onto the skin in addition to speeding up the glycation process.

A.G.E. Interrupter Advanced + RF Microneedling Treatments
Reverse visible signs of aging impacted by glycation by integrating energy-based treatments like RF microneedling. Together, A.G.E. Interrupter Advanced and skin-tightening RF microneedling treatments can help reverse the erosion elasticity and firmness caused by glycation with targeted deep-tissue wrinkle correction. A.G.E. Interrupter Advanced is physician tested to complement RF microneedling treatments and provide 3x better lifting results in 12 weeks.

A.G.E. Routine for GLP-1 Users
GLP-1 medications can contribute to accelerated visible aging, including loss of facial volume, diminished skin elasticity, and increased skin laxity. The A.G.E. routine, featuring A.G.E. Interrupter Advanced and A.G.E. Interrupter Ultra Serum, is physician-tested to reverse skin laxity for GLP-1 patients in just 4 weeks.

Key Ingredients
Proxylane™
Derived from beech wood through an environmentally-efficient process, Proxylane™ helps support the skin’s matrix and restores water to skin. Proxylane™ is easily biodegradable, non-bioaccumulatable, and non-eco-toxic.

Wild Fruit Flavonoids
Combination of blueberry and pomegranate extracts help reduce oxidative stresCB3:CD3s, which can be linked to A.G.E. formation, and protect against free radical damage.

Glycyrrhetinic Acid
Helps counter dull tone, which can be linked to A.G.E. accumulation, and is known for its soothing properties.

Niacinamide (Vitamin B3)
Discover the benefits of niacinamide (vitamin B3), an effective antioxidant that offers powerful environmental protection while being gentle enough for daily use or sensitive skin types.

How to Use A.G.E. Interrupter Advanced
1 Prep + Dispense
Twice daily, massage a thin, even layer of A.G.E. Interrupter Advanced wrinkle cream onto the entire face, neck, and chest.

2 Apply + Complete
If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.